Multiple Sequence Alignment Accuracy and Phylogenetic Inference
نویسندگان
چکیده
منابع مشابه
Multiple sequence alignment accuracy and phylogenetic inference.
Phylogenies are often thought to be more dependent upon the specifics of the sequence alignment rather than on the method of reconstruction. Simulation of sequences containing insertion and deletion events was performed in order to determine the role that alignment accuracy plays during phylogenetic inference. Data sets were simulated for pectinate, balanced, and random tree shapes under differ...
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Multiple sequence alignment is discussed in light of homology assessments in phylogenetic research. Pairwise and multiple alignment methods are reviewed as exact and heuristic procedures. Since the object of alignment is to create the most efficient statement of initial homology, methods that minimize nonhomology are to be favored. Therefore, among all possible alignments, the one that satisfie...
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Constructing Phylogenetic Trees using Multiple Sequence Alignment Ryan M. Potter Chair of the Supervisory Committee: Professor Isabelle Bichindaritz Computing and Software Systems Phylogenetics is the study of evolutionary relatedness amongst organisms. The genetic relationships between species can be represented using phylogenetic trees. Advances in genomics have enriched the range of computat...
متن کاملTCS: a new multiple sequence alignment reliability measure to estimate alignment accuracy and improve phylogenetic tree reconstruction.
Multiple sequence alignment (MSA) is a key modeling procedure when analyzing biological sequences. Homology and evolutionary modeling are the most common applications of MSAs. Both are known to be sensitive to the underlying MSA accuracy. In this work, we show how this problem can be partly overcome using the transitive consistency score (TCS), an extended version of the T-Coffee scoring scheme...
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ژورنال
عنوان ژورنال: Systematic Biology
سال: 2006
ISSN: 1063-5157,1076-836X
DOI: 10.1080/10635150500541730